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Toward structure-based drug design against the epidermal growth factor receptor (EGFR)
Most of the available crystal structures of epidermal growth factor receptor (EGFR) kinase domain, bound to drug inhibitors, originated from ligand-based drug design studies. Here, we used variations in 110 crystal structures to assemble eight distinct families highlighting the C-helix orientation i...
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| Publicat a: | Drug Discov Today |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier Ltd.
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7567673/ https://ncbi.nlm.nih.gov/pubmed/33075469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2020.10.007 |
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