TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model

Because inflammation in osteoarthritis (OA) is related to the Toll-like receptor 4 (TLR4) signaling cascades, TLR4 is a reasonable target for developing therapeutics for OA. Thus, we investigated whether TAP2, a peptide antagonist of TLR4, reduces the monoiodoacetate (MIA)-induced arthritic pain and...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Park, Hyewon, Hong, Jinpyo, Yin, Yuhua, Joo, Yongbum, Kim, Youngmo, Shin, Juhee, Kwon, Hyeok Hee, Shin, Nara, Shin, Hyo Jung, Beom, Jaewon, Kim, Dong Woon, Kim, Jinhyun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567100/
https://ncbi.nlm.nih.gov/pubmed/33060735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74544-5
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