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Selective inhibition of arginase-2 in endothelial cells but not proximal tubules reduces renal fibrosis

Fibrosis is the final common pathway in the pathophysiology of most forms of chronic kidney disease (CKD). As treatment of renal fibrosis still remains largely supportive, a refined understanding of the cellular and molecular mechanisms of kidney fibrosis and the development of novel compounds are u...

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Detalles Bibliográficos
Publicado en:JCI Insight
Main Authors: Wetzel, Michael D., Stanley, Kristen, Wang, Wei Wei, Maity, Soumya, Madesh, Muniswamy, Reeves, W. Brian, Awad, Alaa S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566719/
https://ncbi.nlm.nih.gov/pubmed/32956070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.142187
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