Single hepatocytes show persistence and transcriptional inactivity of hepatitis B

There is no cure for the more than 270 million people chronically infected with HBV. Nucleos(t)ide analogs (NUCs), the mainstay of anti-HBV treatment, block HBV reverse transcription. NUCs do not eliminate the intranuclear covalently closed circular DNA (cccDNA), from which viral RNAs, including pre...

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Publicado en:JCI Insight
Main Authors: Balagopal, Ashwin, Grudda, Tanner, Ribeiro, Ruy M., Saad, Yasmeen S., Hwang, Hyon S., Quinn, Jeffrey, Murphy, Michael, Ward, Kathleen, Sterling, Richard K., Zhang, Yang, Perelson, Alan S., Sulkowski, Mark S., Osburn, William O., Thio, Chloe L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566712/
https://ncbi.nlm.nih.gov/pubmed/33004689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.140584
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