Single hepatocytes show persistence and transcriptional inactivity of hepatitis B

There is no cure for the more than 270 million people chronically infected with HBV. Nucleos(t)ide analogs (NUCs), the mainstay of anti-HBV treatment, block HBV reverse transcription. NUCs do not eliminate the intranuclear covalently closed circular DNA (cccDNA), from which viral RNAs, including pre...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Balagopal, Ashwin, Grudda, Tanner, Ribeiro, Ruy M., Saad, Yasmeen S., Hwang, Hyon S., Quinn, Jeffrey, Murphy, Michael, Ward, Kathleen, Sterling, Richard K., Zhang, Yang, Perelson, Alan S., Sulkowski, Mark S., Osburn, William O., Thio, Chloe L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566712/
https://ncbi.nlm.nih.gov/pubmed/33004689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.140584
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