Aberrant methylation underlies insulin gene expression in human insulinoma

Human insulinomas are rare, benign, slowly proliferating, insulin-producing beta cell tumors that provide a molecular “recipe” or “roadmap” for pathways that control human beta cell regeneration. An earlier study revealed abnormal methylation in the imprinted p15.5-p15.4 region of chromosome 11, kno...

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Published in:Nat Commun
Main Authors: Karakose, Esra, Wang, Huan, Inabnet, William, Thakker, Rajesh V., Libutti, Steven, Fernandez-Ranvier, Gustavo, Suh, Hyunsuk, Stevenson, Mark, Kinoshita, Yayoi, Donovan, Michael, Antipin, Yevgeniy, Li, Yan, Liu, Xiaoxiao, Jin, Fulai, Wang, Peng, Uzilov, Andrew, Argmann, Carmen, Schadt, Eric E., Stewart, Andrew F., Scott, Donald K., Lambertini, Luca
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566641/
https://ncbi.nlm.nih.gov/pubmed/33060578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18839-1
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