Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas

Although diabetes results in part from a deficiency of normal pancreatic beta cells, inducing human beta cells to regenerate is difficult. Reasoning that insulinomas hold the “genomic recipe” for beta cell expansion, we surveyed 38 human insulinomas to obtain insights into therapeutic pathways for b...

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Publicado no:Nat Commun
Main Authors: Wang, Huan, Bender, Aaron, Wang, Peng, Karakose, Esra, Inabnet, William B., Libutti, Steven K., Arnold, Andrew, Lambertini, Luca, Stang, Micheal, Chen, Herbert, Kasai, Yumi, Mahajan, Milind, Kinoshita, Yayoi, Fernandez-Ranvier, Gustavo, Becker, Thomas C., Takane, Karen K., Walker, Laura A., Saul, Shira, Chen, Rong, Scott, Donald K., Ferrer, Jorge, Antipin, Yevgeniy, Donovan, Michael, Uzilov, Andrew V., Reva, Boris, Schadt, Eric E., Losic, Bojan, Argmann, Carmen, Stewart, Andrew F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626682/
https://ncbi.nlm.nih.gov/pubmed/28974674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00992-9
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