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Determinants of protein function revealed by combinatorial entropy optimization
We use a new algorithm (combinatorial entropy optimization [CEO]) to identify specificity residues and functional subfamilies in sets of proteins related by evolution. Specificity residues are conserved within a subfamily but differ between subfamilies, and they typically encode functional diversity...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2258190/ https://ncbi.nlm.nih.gov/pubmed/17976239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2007-8-11-r232 |
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