Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af...

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Pubblicato in:Nat Commun
Autori principali: Nowak, Kathrin, Rosenthal, Florian, Karlberg, Tobias, Bütepage, Mareike, Thorsell, Ann-Gerd, Dreier, Birgit, Grossmann, Jonas, Sobek, Jens, Imhof, Ralph, Lüscher, Bernhard, Schüler, Herwig, Plückthun, Andreas, Leslie Pedrioli, Deena M., Hottiger, Michael O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566600/
https://ncbi.nlm.nih.gov/pubmed/33060572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18981-w
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