Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Nowak, Kathrin, Rosenthal, Florian, Karlberg, Tobias, Bütepage, Mareike, Thorsell, Ann-Gerd, Dreier, Birgit, Grossmann, Jonas, Sobek, Jens, Imhof, Ralph, Lüscher, Bernhard, Schüler, Herwig, Plückthun, Andreas, Leslie Pedrioli, Deena M., Hottiger, Michael O.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566600/
https://ncbi.nlm.nih.gov/pubmed/33060572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18981-w
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