Stress-induced RNA–chromatin interactions promote endothelial dysfunction

Chromatin-associated RNA (caRNA) has been proposed as a type of epigenomic modifier. Here, we test whether environmental stress can induce cellular dysfunction through modulating RNA-chromatin interactions. We induce endothelial cell (EC) dysfunction with high glucose and TNFα (H + T), that mimic th...

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Udgivet i:Nat Commun
Main Authors: Calandrelli, Riccardo, Xu, Lixia, Luo, Yingjun, Wu, Weixin, Fan, Xiaochen, Nguyen, Tri, Chen, Chien-Ju, Sriram, Kiran, Tang, Xiaofang, Burns, Andrew B., Natarajan, Rama, Chen, Zhen Bouman, Zhong, Sheng
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566596/
https://ncbi.nlm.nih.gov/pubmed/33060583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18957-w
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