microRNA-seq of cartilage reveals an overabundance of miR-140-3p which contains functional isomiRs

miR-140 is selectively expressed in cartilage. Deletion of the entire Mir140 locus in mice results in growth retardation and early-onset osteoarthritis-like pathology; however, the relative contribution of miR-140-5p or miR-140-3p to the phenotype remains to be determined. An unbiased small RNA sequ...

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Pubblicato in:RNA
Autori principali: Woods, Steven, Charlton, Sarah, Cheung, Kat, Hao, Yao, Soul, Jamie, Reynard, Louise N., Crowe, Natalie, Swingler, Tracey E., Skelton, Andrew J., Piróg, Katarzyna A., Miles, Colin G., Tsompani, Dimitra, Jackson, Robert M., Dalmay, Tamas, Clark, Ian M., Barter, Matt J., Young, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566571/
https://ncbi.nlm.nih.gov/pubmed/32660984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.075176.120
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