Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma

BACKGROUND: Glioblastoma is associated with poor prognosis and high mortality. Although the use of first-line temozolomide can reduce tumor growth, therapy-induced stress drives stem cells out of quiescence, leading to chemoresistance and glioblastoma recurrence. The specificity protein 1 (Sp1) tran...

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Udgivet i:Neuro Oncol
Main Authors: Yang, Wen-Bin, Hsu, Che-Chia, Hsu, Tsung-I, Liou, Jing-Ping, Chang, Kwang-Yu, Chen, Pin-Yuan, Liu, Jr-Jiun, Yang, Shung-Tai, Wang, Jia-Yi, Yeh, Shiu-Hwa, Chen, Ruei-Ming, Chang, Wen-Chang, Chuang, Jian-Ying
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566541/
https://ncbi.nlm.nih.gov/pubmed/32328646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa103
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