Tumor somatic mutations also existing as germline polymorphisms may help to identify functional SNPs from genome-wide association studies

We hypothesized that a joint analysis of cancer risk-associated single-nucleotide polymorphism (SNP) and somatic mutations in tumor samples can predict functional and potentially causal SNPs from GWASs. We used mutations reported in the Catalog of Somatic Mutations in Cancer (COSMIC). Confirmed soma...

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Dades bibliogràfiques
Publicat a:Carcinogenesis
Autors principals: Gorlov, Ivan P, Xia, Xiangjun, Tsavachidis, Spiridon, Gorlova, Olga Y, Amos, Christopher I
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Cancer Biomarkers and Molecular Epidemiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566444/
https://ncbi.nlm.nih.gov/pubmed/32681635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgaa077
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