Human germinal centres engage memory and naïve B cells after influenza vaccination

Influenza viruses remain a major public health threat. Seasonal influenza vaccination in humans primarily stimulates pre-existing memory B cells, leading to a transient wave of circulating antibody-secreting plasmablasts(1–3). This recall response contributes to “original antigenic sin,” the selecti...

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Publicado no:Nature
Main Authors: Turner, Jackson S., Zhou, Julian Q., Han, Julianna, Schmitz, Aaron J., Rizk, Amena A., Alsoussi, Wafaa B., Lei, Tingting, Amor, Mostafa, McIntire, Katherine M., Meade, Philip, Strohmeier, Shirin, Brent, Rafael I., Richey, Sara T., Haile, Alem, Yang, Yuhe R., Klebert, Michael K., Suessen, Teresa, Teefey, Sharlene, Presti, Rachel M., Krammer, Florian, Kleinstein, Steven H., Ward, Andrew B., Ellebedy, Ali H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566073/
https://ncbi.nlm.nih.gov/pubmed/32866963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2711-0
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