SMAC Mimetic Plus Triple-Combination Bispecific HIVxCD3 Retargeting Molecules in SHIV.C.CH505-Infected, Antiretroviral Therapy-Suppressed Rhesus Macaques

The “shock-and-kill” human immunodeficiency virus type 1 (HIV-1) cure strategy involves latency reversal followed by immune-mediated clearance of infected cells. We have previously shown that activation of the noncanonical NF-κB pathway using an inhibitor of apoptosis (IAP), AZD5582, reverses HIV/si...

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Udgivet i:J Virol
Main Authors: Dashti, Amir, Waller, Chevaughn, Mavigner, Maud, Schoof, Nils, Bar, Katharine J., Shaw, George M., Vanderford, Thomas H., Liang, Shan, Lifson, Jeffrey D., Dunham, Richard M., Ferrari, Guido, Tuyishime, Marina, Lam, Chia-Ying K., Nordstrom, Jeffrey L., Margolis, David M., Silvestri, Guido, Chahroudi, Ann
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7565632/
https://ncbi.nlm.nih.gov/pubmed/32817214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00793-20
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