Matrix Metalloproteinase-11 Promotes Early Mouse Mammary Gland Tumor Growth through Metabolic Reprogramming and Increased IGF1/AKT/FoxO1 Signaling Pathway, Enhanced ER Stress and Alteration in Mitochondrial UPR

Matrix metalloproteinase 11 (MMP11) is an extracellular proteolytic enzyme belonging to the matrix metalloproteinase (MMP11) family. These proteases are involved in extracellular matrix (ECM) remodeling and activation of latent factors. MMP11 is a negative regulator of adipose tissue development and...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Tan, Bing, Jaulin, Amélie, Bund, Caroline, Outilaft, Hassiba, Wendling, Corinne, Chenard, Marie-Pierrette, Alpy, Fabien, Cicek, A. Ercüment, Namer, Izzie J., Tomasetto, Catherine, Dali-Youcef, Nassim
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7565046/
https://ncbi.nlm.nih.gov/pubmed/32825455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12092357
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