Mendelian randomization case-control PheWAS in UK Biobank shows evidence of causality for smoking intensity in 28 distinct clinical conditions

BACKGROUND: Smoking is one of the greatest threats to public health worldwide. We integrated phenome-wide association study (PheWAS) and Mendelian randomization (MR) approaches to explore causal effects of genetically predicted smoking intensity across the human disease spectrum. METHODS: We conduct...

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Gepubliceerd in:EClinicalMedicine
Hoofdauteurs: King, Catherine, Mulugeta, Anwar, Nabi, Farhana, Walton, Robert, Zhou, Ang, Hyppönen, Elina
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7564324/
https://ncbi.nlm.nih.gov/pubmed/33089118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eclinm.2020.100488
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