MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank

OBJECTIVES: We aimed to investigate the role of serum uric acid (SUA) level in a broad spectrum of disease outcomes using data for 120 091 individuals from UK Biobank. METHODS: We performed a phenome-wide association study (PheWAS) to identify disease outcomes associated with SUA genetic risk loci....

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Veröffentlicht in:Ann Rheum Dis
Hauptverfasser: Li, Xue, Meng, Xiangrui, Spiliopoulou, Athina, Timofeeva, Maria, Wei, Wei-Qi, Gifford, Aliya, Shen, Xia, He, Yazhou, Varley, Tim, McKeigue, Paul, Tzoulaki, Ioanna, Wright, Alan F, Joshi, Peter, Denny, Joshua C, Campbell, Harry, Theodoratou, Evropi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2018
Schlagworte:
Clinical and Epidemiological Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029646/
https://ncbi.nlm.nih.gov/pubmed/29437585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2017-212534
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