Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA

Hybrid nanoparticles from lipidic and polymeric components were assembled to serve as vehicles for the transfection of messenger RNA (mRNA) using different portions of the cationic lipid DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane) and the cationic biopolymer protamine as model systems. Two diff...

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Main Authors: Siewert, Christian D., Haas, Heinrich, Cornet, Vera, Nogueira, Sara S., Nawroth, Thomas, Uebbing, Lukas, Ziller, Antje, Al-Gousous, Jozef, Radulescu, Aurel, Schroer, Martin A., Blanchet, Clement E., Svergun, Dmitri I., Radsak, Markus P., Sahin, Ugur, Langguth, Peter
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2020
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7563888/
https://ncbi.nlm.nih.gov/pubmed/32899484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9092034
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