Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA

Hybrid nanoparticles from lipidic and polymeric components were assembled to serve as vehicles for the transfection of messenger RNA (mRNA) using different portions of the cationic lipid DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane) and the cationic biopolymer protamine as model systems. Two diff...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Siewert, Christian D., Haas, Heinrich, Cornet, Vera, Nogueira, Sara S., Nawroth, Thomas, Uebbing, Lukas, Ziller, Antje, Al-Gousous, Jozef, Radulescu, Aurel, Schroer, Martin A., Blanchet, Clement E., Svergun, Dmitri I., Radsak, Markus P., Sahin, Ugur, Langguth, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7563888/
https://ncbi.nlm.nih.gov/pubmed/32899484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9092034
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