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Distribution of disease-causing germline mutations in coiled-coils implies an important role of their N-terminal region
Next-generation sequencing resulted in the identification of a huge number of naturally occurring variations in human proteins. The correct interpretation of the functional effects of these variations necessitates the understanding of how they modulate protein structure. Coiled-coils are α-helical s...
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| Udgivet i: | Sci Rep |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7562717/ https://ncbi.nlm.nih.gov/pubmed/33060664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74354-9 |
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