Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation

The most frequent genetic alterations across multiple human cancers are mutations in TP53 and the activation of the PI3K/AKT pathway, two events crucial for cancer progression. Mutations in TP53 lead to the inhibition of the tumour and metastasis suppressor TAp63, a p53 family member. By performing...

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Udgivet i:Nat Commun
Main Authors: Napoli, Marco, Li, Xiaobo, Ackerman, Hayley D., Deshpande, Avani A., Barannikov, Ivan, Pisegna, Marlese A., Bedrosian, Isabelle, Mitsch, Jürgen, Quinlan, Philip, Thompson, Alastair, Rajapakshe, Kimal, Coarfa, Cristian, Gunaratne, Preethi H., Marchion, Douglas C., Magliocco, Anthony M., Tsai, Kenneth Y., Flores, Elsa R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561725/
https://ncbi.nlm.nih.gov/pubmed/33056990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18973-w
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