Pharmacodynamics of glyburide, metformin and glyburide/metformin combination therapy in the treatment of gestational diabetes mellitus

In gestational diabetes mellitus (GDM), women are unable to compensate for the increased insulin resistance during pregnancy. Data are limited regarding the pharmacodynamic effects of metformin and glyburide during pregnancy. This study characterized insulin sensitivity (SI), β-cell responsivity, an...

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Gepubliceerd in:Clin Pharmacol Ther
Hoofdauteurs: Shuster, Diana L., Shireman, Laura M., Ma, Xiaosu, Shen, Danny D., Nichols, Shannon K. Flood, Ahmed, Mahmoud S., Clark, Shannon, Caritis, Steve, Venkataramanan, Raman, Haas, David M., Quinney, Sara K., Haneline, Laura S., Tita, Alan T., Manuck, Tracy A., Thummel, Kenneth E., Brown, Linda Morris, Ren, Zhaoxia, Brown, Zane, Easterling, Thomas R., Hebert, Mary F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561209/
https://ncbi.nlm.nih.gov/pubmed/31869430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1749
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