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TRPM7 channel activity in Jurkat T lymphocytes during magnesium depletion and loading: implications for divalent metal entry and cytotoxicity

TRPM7 is a cation channel-protein kinase highly expressed in T lymphocytes and other immune cells. It has been proposed to constitute a cellular entry pathway for Mg(2+) and divalent metal cations such as Ca(2+), Zn(2+), Cd(2+), Mn(2+)and Ni(2+). TRPM7 channels are inhibited by cytosolic Mg(2+), ren...

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Vydáno v:Pflugers Arch
Hlavní autoři: Mellott, Alayna, Rockwood, Jananie, Zhelay, Tetyana, Luu, Charles Tuan, Kaitsuka, Taku, Kozak, J. Ashot
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561021/
https://ncbi.nlm.nih.gov/pubmed/32964285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-020-02457-3
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