Autocrine TGF-β1/miR-200s/miR-221/DNMT3B regulatory loop maintains CAF status to fuel breast cancer cell proliferation

Cancer-associated fibroblasts (CAFs) remain active even in the absence of cancer cells. However, the molecular mechanism underlying the sustained active status of CAFs is largely unrevealed. We found that in CAFs, DNMT3B was not only a target of miR-200b, miR-200c and miR-221, but was able to induce...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Tang, Xi, Tu, Gang, Yang, Guanglun, Wang, Xing, Kang, Linmin, Yang, Liping, Zeng, Huan, Wan, Xueying, Qiao, Yina, Cui, Xiaojiang, Liu, Manran, Hou, Yixuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560952/
https://ncbi.nlm.nih.gov/pubmed/30851420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2019.02.044
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