Autocrine TGF-β1/miR-200s/miR-221/DNMT3B regulatory loop maintains CAF status to fuel breast cancer cell proliferation

Cancer-associated fibroblasts (CAFs) remain active even in the absence of cancer cells. However, the molecular mechanism underlying the sustained active status of CAFs is largely unrevealed. We found that in CAFs, DNMT3B was not only a target of miR-200b, miR-200c and miR-221, but was able to induce...

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Detaylı Bibliyografya
Yayımlandı:Cancer Lett
Asıl Yazarlar: Tang, Xi, Tu, Gang, Yang, Guanglun, Wang, Xing, Kang, Linmin, Yang, Liping, Zeng, Huan, Wan, Xueying, Qiao, Yina, Cui, Xiaojiang, Liu, Manran, Hou, Yixuan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560952/
https://ncbi.nlm.nih.gov/pubmed/30851420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2019.02.044
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