Epithelial WNT2B and Desert Hedgehog Are Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury

Intestinal regeneration and crypt hyperplasia after radiation or pathogen injury relies on Wnt signaling to stimulate stem cell proliferation. Mesenchymal Wnts are essential for homeostasis and regeneration in mice, but the role of epithelial Wnts remains largely uncharacterized. Using the enterohem...

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Publicado no:iScience
Main Authors: In, Julie G., Yin, Jianyi, Atanga, Roger, Doucet, Michele, Cole, Robert N., DeVine, Lauren, Donowitz, Mark, Zachos, Nicholas C., Blutt, Sarah E., Estes, Mary K., Kovbasnjuk, Olga
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7559866/
https://ncbi.nlm.nih.gov/pubmed/33089106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101618
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