Epithelial WNT2B and Desert Hedgehog Are Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury

Intestinal regeneration and crypt hyperplasia after radiation or pathogen injury relies on Wnt signaling to stimulate stem cell proliferation. Mesenchymal Wnts are essential for homeostasis and regeneration in mice, but the role of epithelial Wnts remains largely uncharacterized. Using the enterohem...

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Publicado en:iScience
Main Authors: In, Julie G., Yin, Jianyi, Atanga, Roger, Doucet, Michele, Cole, Robert N., DeVine, Lauren, Donowitz, Mark, Zachos, Nicholas C., Blutt, Sarah E., Estes, Mary K., Kovbasnjuk, Olga
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7559866/
https://ncbi.nlm.nih.gov/pubmed/33089106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101618
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