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Influence of Probenecid on the Pharmacokinetics and Pharmacodynamics of Sorafenib
Prior studies have demonstrated an organic anion transporter 6 (OAT6)-mediated accumulation of sorafenib in keratinocytes. The OAT6 inhibitor probenecid decreases sorafenib uptake in skin and might, therefore, decrease sorafenib-induced cutaneous adverse events. Here, the influence of probenecid on...
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| Publié dans: | Pharmaceutics |
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| Auteurs principaux: | , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7559746/ https://ncbi.nlm.nih.gov/pubmed/32825359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12090788 |
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