Influence of Probenecid on the Pharmacokinetics and Pharmacodynamics of Sorafenib

Prior studies have demonstrated an organic anion transporter 6 (OAT6)-mediated accumulation of sorafenib in keratinocytes. The OAT6 inhibitor probenecid decreases sorafenib uptake in skin and might, therefore, decrease sorafenib-induced cutaneous adverse events. Here, the influence of probenecid on...

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Detalhes bibliográficos
Publicado no:Pharmaceutics
Main Authors: Hussaarts, Koen G. A. M., van Doorn, Leni, Eechoute, Karel, Damman, Jeffrey, Fu, Qiang, van Doorn, Nadia, Eisenmann, Eric D., Gibson, Alice A., Oomen-de Hoop, Esther, de Bruijn, Peter, Baker, Sharyn D., Koolen, Stijn L. W., van Gelder, Teun, van Leeuwen, Roelof W. F., Mathijssen, Ron H. J., Sparreboom, Alex, Bins, Sander
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7559746/
https://ncbi.nlm.nih.gov/pubmed/32825359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12090788
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