Adipocytes fail to maintain cellular identity during obesity due to reduced PPARγ activity and elevated TGFβ-SMAD signaling

OBJECTIVE: Obesity due to overnutrition causes adipose tissue dysfunction, which is a critical pathological step on the road to type 2 diabetes (T2D) and other metabolic disorders. In this study, we conducted an unbiased investigation into the fundamental molecular mechanisms by which adipocytes tra...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Roh, Hyun Cheol, Kumari, Manju, Taleb, Solaema, Tenen, Danielle, Jacobs, Christopher, Lyubetskaya, Anna, Tsai, Linus T.-Y., Rosen, Evan D.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7559520/
https://ncbi.nlm.nih.gov/pubmed/32992037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101086
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