Drug-induced cholestasis assay in primary hepatocytes

Drug-induced cholestasis (DIC) is a major cause of clinical failure of drug candidates. Numerous patients worldwide are affected when exposed to marketed drugs exhibiting a DIC signature. Prospective identification of DIC during early compound development remains challenging. Here we describe the op...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:MethodsX
Egile Nagusiak: Van Brantegem, Pieter, Chatterjee, Sagnik, De Bruyn, Tom, Annaert, Pieter, Deferm, Neel
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2020
Gaiak:
Method Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7559231/
https://ncbi.nlm.nih.gov/pubmed/33088729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mex.2020.101080
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