JMX0207, a Niclosamide Derivative with Improved Pharmacokinetics, Suppresses Zika Virus Infection Both In Vitro and In Vivo

Flaviviruses causes significant human disease. Recent outbreaks of the Zika virus highlight the need to develop effective therapies for this class of viruses. Previously we identified niclosamide as a broad-spectrum inhibitor for flaviviruses by targeting the interface between viral protease NS3 and...

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Publicado no:ACS Infect Dis
Main Authors: Li, Zhong, Xu, Jimin, Lang, Yuekun, Fan, Xiaoyu, Kuo, Lili, D’Brant, Lianna, Hu, Saiyang, Samrat, Subodh Kumar, Trudeau, Nicole, Tharappel, Anil M., Rugenstein, Natasha, Koetzner, Cheri A., Zhang, Jing, Chen, Haiying, Kramer, Laura D., Butler, David, Zhang, Qing-Yu, Zhou, Jia, Li, Hongmin
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7559020/
https://ncbi.nlm.nih.gov/pubmed/32866370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00217
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