Saponin Micelles Lead to High Mucosal Permeation and In Vivo Efficacy of Solubilized Budesonide

Due to fast nasal mucociliary clearance, only the dissolved drug content can effectively permeate the mucosa and be pharmaceutically active after intranasal application of suspensions. Therefore, the aim of this study was to increase the budesonide concentration in solution of a nasal spray formulat...

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Publicat a:Pharmaceutics
Autors principals: Nakowitsch, Sabine, Koller, Christiane, Seifert, Jan-Marcus, König-Schuster, Marielle, Unger-Manhart, Nicole, Siegl, Cornelia, Kirchoff, Norman, Foglar, Elisabeth, Graf, Christine, Morokutti-Kurz, Martina, Neurath, Marianne, Sladek, Svenja, Knecht, Christian, Sipos, Wolfgang, Prieschl-Grassauer, Eva, Grassauer, Andreas
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7558607/
https://ncbi.nlm.nih.gov/pubmed/32899549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12090847
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