Saponin Micelles Lead to High Mucosal Permeation and In Vivo Efficacy of Solubilized Budesonide

Due to fast nasal mucociliary clearance, only the dissolved drug content can effectively permeate the mucosa and be pharmaceutically active after intranasal application of suspensions. Therefore, the aim of this study was to increase the budesonide concentration in solution of a nasal spray formulat...

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Publicado en:Pharmaceutics
Autores principales: Nakowitsch, Sabine, Koller, Christiane, Seifert, Jan-Marcus, König-Schuster, Marielle, Unger-Manhart, Nicole, Siegl, Cornelia, Kirchoff, Norman, Foglar, Elisabeth, Graf, Christine, Morokutti-Kurz, Martina, Neurath, Marianne, Sladek, Svenja, Knecht, Christian, Sipos, Wolfgang, Prieschl-Grassauer, Eva, Grassauer, Andreas
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7558607/
https://ncbi.nlm.nih.gov/pubmed/32899549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12090847
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