Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon

BACKGROUND: The mechanisms underlying altered susceptibility and propensity to severe Coronavirus disease 2019 (COVID-19) disease in at-risk groups such as patients with chronic obstructive pulmonary disease (COPD) are poorly understood. Inhaled corticosteroids (ICSs) are widely used in COPD, but th...

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Pubblicato in:J Allergy Clin Immunol
Autori principali: Finney, Lydia J., Glanville, Nicholas, Farne, Hugo, Aniscenko, Julia, Fenwick, Peter, Kemp, Samuel V., Trujillo-Torralbo, Maria-Belen, Loo, Su Ling, Calderazzo, Maria Adelaide, Wedzicha, Jadwiga A., Mallia, Patrick, Bartlett, Nathan W., Johnston, Sebastian L., Singanayagam, Aran
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mosby 2021
Soggetti:
Covid-19
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7558236/
https://ncbi.nlm.nih.gov/pubmed/33068560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2020.09.034
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