Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease

Bacterial infection commonly complicates inflammatory airway diseases such as chronic obstructive pulmonary disease (COPD). The mechanisms of increased infection susceptibility and how use of the commonly prescribed therapy inhaled corticosteroids (ICS) accentuates pneumonia risk in COPD is poorly u...

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Publicado no:Sci Transl Med
Main Authors: Singanayagam, Aran, Glanville, Nicholas, Cuthbertson, Leah, Bartlett, Nathan W, Finney, Lydia J, Turek, Elena, Bakhsoliani, Eteri, Calderazzo, Maria A, Trujillo-Torralbo, MariaBelen, Footitt, Joseph, James, Phillip L, Fenwick, Peter, Kemp, Samuel V, Clarke, Thomas B, Wedzicha, Jadwiga A, Edwards, Michael R, Moffatt, Miriam, Cookson, William O, Mallia, Patrick, Johnston, Sebastian L
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7237237/
https://ncbi.nlm.nih.gov/pubmed/31462509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav3879
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