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Simultaneous Quantification of Protein Binding Kinetics in Whole Cells with Surface Plasmon Resonance Imaging and Edge Deformation Tracking

Most drugs work by binding to receptors on the cell surface. Quantification of binding kinetics between drug and membrane protein is an essential step in drug discovery. Current methods for measuring binding kinetics involve extracting the membrane protein and labeling, and both have issues. Surface...

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Dettagli Bibliografici
Pubblicato in:Membranes (Basel)
Autori principali: Jing, Wenwen, Hunt, Ashley, Tao, Nongjian, Zhang, Fenni, Wang, Shaopeng
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7558147/
https://ncbi.nlm.nih.gov/pubmed/32971834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/membranes10090247
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