Lovastatin improves endothelial dysfunction and cellular crosstalk in LMNA-related dilated cardiomyopathy

Mutations in LMNA, the gene that encodes lamin A and C, causes LMNA-related dilated cardiomyopathy (DCM), or cardiolaminopathy. LMNA is expressed in endothelial cells (ECs), however, little is known about the EC-specific phenotype of LMNA-related DCM. Here we studied a family affected by DCM due to...

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Udgivet i:Sci Transl Med
Main Authors: Sayed, Nazish, Liu, Chun, Ameen, Mohamed, Himmati, Farhan, Zhang, Joe Z., Khanamiri, Saereh, Moonen, Jan-Renier, Wnorowski, Alexa, Cheng, Linling, Rhee, June-Wha, Gaddam, Sadhana, Wang, Kevin C., Sallam, Karim, Woo, Y. Joseph, Rabinovitch, Marlene, Wu, Joseph C.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7557117/
https://ncbi.nlm.nih.gov/pubmed/32727917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax9276
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