Activation of PDGF Pathway Links LMNA Mutation to Dilated Cardiomyopathy

Lamin A/C (LMNA) is one of the most frequently mutated genes in dilated cardiomyopathy (DCM). LMNA-related DCM is a common inherited cardiomyopathy associated with systolic dysfunction and high prevalence arrhythmias. Here we modeled the LMNA-DCM in vitro using patient-specific induced pluripotent s...

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Publicado no:Nature
Main Authors: Lee, Jaecheol, Termglinchan, Vittavat, Diecke, Sebastian, Itzhaki, Ilanit, Lam, Chi Keung, Garg, Priyanka, Lau, Edward, Greenhaw, Matthew, Seeger, Timon, Wu, Haodi, Zhang, Joe Z., Chen, Xingqi, Gil, Isaac Perea, Ameen, Mohamed, Sallam, Karim, Rhee, June-Wha, Churko, Jared, Chaudhary, Rinkal, Chour, Tony, Wang, Paul J., Snyder, Michael P., Chang, Howard Y, Karakikes, Ioannis, Wu, Joseph C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779479/
https://ncbi.nlm.nih.gov/pubmed/31316208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1406-x
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