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WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells

BACKGROUND: The Werner syndrome protein (WRN) belongs to the RecQ family of helicases and its loss of function results in the premature aging disease Werner syndrome (WS). We previously demonstrated that an early cellular change induced by WRN depletion is a posttranscriptional decrease in the level...

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Detalles Bibliográficos
Publicado en:BMC Mol Cell Biol
Main Authors: Iglesias-Pedraz, Juan Manuel, Fossatti-Jara, Diego Matia, Valle-Riestra-Felice, Valeria, Cruz-Visalaya, Sergio Rafael, Ayala Felix, Jose Antonio, Comai, Lucio
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7557079/
https://ncbi.nlm.nih.gov/pubmed/33054770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-020-00315-9
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