A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

Glioblastomas exhibit vast inter- and intra-tumoral heterogeneity, complicating the development of effective therapeutic strategies. Current in vitro models are limited in preserving the cellular and mutational diversity of parental tumors and require a prolonged generation time. Here, we report met...

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Veröffentlicht in:Cell
Hauptverfasser: Jacob, Fadi, Salinas, Ryan D., Zhang, Daniel Y., Nguyen, Phuong T.T., Schnoll, Jordan G., Wong, Samuel Zheng Hao, Thokala, Radhika, Sheikh, Saad, Saxena, Deeksha, Prokop, Stefan, Liu, Di-ao, Qian, Xuyu, Petrov, Dmitriy, Lucas, Timothy, Chen, H. Isaac, Dorsey, Jay F., Christian, Kimberly M., Binder, Zev A., Nasrallah, MacLean, Brem, Steven, O’Rourke, Donald M., Ming, Guo-li, Song, Hongjun
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556703/
https://ncbi.nlm.nih.gov/pubmed/31883794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.11.036
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