RAL GTPases mediate multiple myeloma cell survival and are activated independently of oncogenic RAS

Oncogenic RAS provides crucial survival signaling for up to half of multiple myeloma (MM) cases, but has so far remained a clinically undruggable target. RAS-like protein (RAL) is a member of the RAS superfamily of small GTPases and is considered to be a potential mediator of oncogenic RAS signaling...

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Publicado en:Haematologica
Main Authors: Seibold, Marcel, Stühmer, Thorsten, Kremer, Nadine, Mottok, Anja, Scholz, Claus-Jürgen, Schlosser, Andreas, Leich, Ellen, Holzgrabe, Ulrike, Brünnert, Daniela, Barrio, Santiago, Kortüm, K. Martin, Solimando, Antonio G., Chatterjee, Manik, Einsele, Hermann, Rosenwald, Andreas, Bargou, Ralf C., Steinbrunn, Torsten
Formato: Artigo
Idioma:Inglês
Publicado: Fondazione Ferrata Storti 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556628/
https://ncbi.nlm.nih.gov/pubmed/33054056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.223024
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