Mitochondrial Energy-Regulating Effect of Atractyloside Inhibits Hepatocellular Steatosis Through the Activation of Autophagy

BACKGROUND AND AIM: Atractyloside (ATR), a mitochondrial uncoupler, is known for its specific inhibition of mitochondrial oxidative phosphorylation. Previous studies have reported that moderate mitochondrial uncoupling effect is beneficial to increase the decomposition and clearance of hepatic lipid...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Zhang, Pengfei, Li, Lijun, Sun, Huimin, Zhang, Yipeng, Zhang, Guoliang, Zhang, Tianyu, Zeng, Changchun
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556285/
https://ncbi.nlm.nih.gov/pubmed/33101031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.575695
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