Mitochondrial Energy-Regulating Effect of Atractyloside Inhibits Hepatocellular Steatosis Through the Activation of Autophagy

BACKGROUND AND AIM: Atractyloside (ATR), a mitochondrial uncoupler, is known for its specific inhibition of mitochondrial oxidative phosphorylation. Previous studies have reported that moderate mitochondrial uncoupling effect is beneficial to increase the decomposition and clearance of hepatic lipid...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Zhang, Pengfei, Li, Lijun, Sun, Huimin, Zhang, Yipeng, Zhang, Guoliang, Zhang, Tianyu, Zeng, Changchun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556285/
https://ncbi.nlm.nih.gov/pubmed/33101031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.575695
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