Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma

Whole genomic and transcriptomic analyses of MEITL revealed multiple potential therapeutic targets. Synergistic effects of pimozide and romidepsin are shown in a well-characterized MEITL PDX model.

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Vydáno v:Blood Adv
Hlavní autoři: Huang, Dachuan, Lim, Jing Quan, Cheah, Daryl Ming Zhe, Kahliab, Khalilatul Hanisah Binte Mohd, Laurensia, Yurike, Pang, Jane Wan Lu, Wong, Esther Kam Yin, Chia, Burton Kuan Hui, Goh, Jasmine, Zhang, Xiyun, Chan, Jason Yongsheng, Chow, Edward Kai-Hua, Tan, Soo Yong, Lim, Soon Thye, Ong, Choon Kiat
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2020
Témata:
Stimulus Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556141/
https://ncbi.nlm.nih.gov/pubmed/33017466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001782
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