Mismatch-Repair Protein Expression in High-Grade Gliomas: A Large Retrospective Multicenter Study

Background: DNA mismatch repair (MMR) is a system for repairing errors in DNA replication. Cancer cells with MMR deficiency can have immunohistochemical loss of MMR protein expression leading to a hypermutable phenotype that may correlate with anti-PD1 efficacy. Scant data exist about immunohistoche...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Caccese, Mario, Ius, Tamara, Simonelli, Matteo, Fassan, Matteo, Cesselli, Daniela, Dipasquale, Angelo, Cavallin, Francesco, Padovan, Marta, Salvalaggio, Alessandro, Gardiman, Marina Paola, Skrap, Miran, Zagonel, Vittorina, Lombardi, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555820/
https://ncbi.nlm.nih.gov/pubmed/32937743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186716
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