Pembrolizumab Activity in Recurrent High-Grade Gliomas with Partial or Complete Loss of Mismatch Repair Protein Expression: A Monocentric, Observational and Prospective Pilot Study

Introduction: Pembrolizumab demonstrated promising results in hypermutated tumors of diverse origin. Immunohistochemical loss of mismatch repair (MMR) proteins has been suggested as a surrogate of hypermutation in high-grade gliomas (HGG). We evaluated the efficacy and safety of pembrolizumab in rel...

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Publicat a:Cancers (Basel)
Autors principals: Lombardi, Giuseppe, Barresi, Valeria, Indraccolo, Stefano, Simbolo, Michele, Fassan, Matteo, Mandruzzato, Susanna, Simonelli, Matteo, Caccese, Mario, Pizzi, Marco, Fassina, Arianna, Padovan, Marta, Masetto, Elena, Gardiman, Marina Paola, Bonavina, Maria Giuseppina, Caffo, Maria, Persico, Pasquale, Chioffi, Franco, Denaro, Luca, Dei Tos, Angelo Paolo, Scarpa, Aldo, Zagonel, Vittorina
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464918/
https://ncbi.nlm.nih.gov/pubmed/32823925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082283
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