The Role of Smoothened in Cancer

Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH ligands, PT...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Jeng, Kuo-Shyang, Sheen, I-Shyan, Leu, Chuen-Miin, Tseng, Ping-Hui, Chang, Chiung-Fang
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555769/
https://ncbi.nlm.nih.gov/pubmed/32962123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186863
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