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Cerebral Vasodilator Property of Poly(ADP-Ribose) Polymerase Inhibitor (PJ34) in the Neonatal and Adult Mouse Is Mediated by the Nitric Oxide Pathway

The poly(ADP-ribose) polymerase (PARP) inhibitor PJ34 has been reported to improve endothelial dysfunction in the peripheral system. We addressed the role of PJ34 on the vascular tone and vasoreactivity during development in the mouse brain. Blood flows were measured in the basilar trunk using ultra...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Bonnin, Philippe, Charriaut-Marlangue, Christiane, Pansiot, Julien, Boutigny, Alexandre, Launay, Jean-Marie, Besson, Valérie C.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555622/
https://ncbi.nlm.nih.gov/pubmed/32911782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186569
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