Targeting Cell Cycle in Breast Cancer: CDK4/6 Inhibitors

Deregulation of cell cycle, via cyclin D/CDK/pRb pathway, is frequently observed in breast cancer lending support to the development of drugs targeting the cell cycle control machinery, like the inhibitors of the cycline-dependent kinases (CDK) 4 and 6. Up to now, three CDK4/6 inhibitors have been a...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Piezzo, Michela, Cocco, Stefania, Caputo, Roberta, Cianniello, Daniela, Gioia, Germira Di, Lauro, Vincenzo Di, Fusco, Giuseppina, Martinelli, Claudia, Nuzzo, Francesco, Pensabene, Matilde, Laurentiis, Michelino De
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7554788/
https://ncbi.nlm.nih.gov/pubmed/32899866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186479
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